Buffalo Bills at Houston Texans Game Predictions | Week 12

Key Highlights

  • Buffalo Bills are 5.5-point road favorites against the Houston Texans in Week 12.
  • The game begins at 8:15 pm on November 20, 2025, and will air on Prime Video (WKBW in Buffalo).
  • Pete Prisco from CBS Sports believes Josh Allen is ready to get on a roll against the Texans’ top-ranked defense.
  • Vinnie Iyer from Sporting News predicts a close game with the Bills winning 23-20 but failing to cover the spread.

Game Overview and Predictions

The Buffalo Bills (7-3) travel to NRG Stadium to face the Houston Texans (5-5) in a highly anticipated Thursday Night Football matchup. The game is scheduled for 8:15 pm on November 20, 2025, with coverage available on Prime Video and local station WKBW in Buffalo.

Bills’ Recent Performance

The Bills have not won in Houston since November 19, 2006. However, they have a strong recent record against Thursday night opponents, having won their last six games. More impressively, the team has scored at least 28 points in all seven of its victories this season and only managed 20 or fewer points in three losses.

Key Player Analysis

Pete Prisco from CBS Sports highlights that Thursday night primetime has been good for Josh Allen. He is 6-0 in these games, setting him up to potentially break a losing streak against the Texans’ top-ranked defense. Meanwhile, Vinnie Iyer notes that while the Bills have faced tough challenges at home against Houston since 2018, Allen’s recent form could tip the scale in favor of a victory.

Texans’ Defense and Strategy

The Texans will start Davis Mills for their injured quarterback C.J. Stroud. The defense presents a significant challenge with its ability to stop the run and pressure the opposing quarterback. Pete Prisco suggests that Allen may be ready to get on a roll, while Vinnie Iyer believes the Bills are still the more complete team despite facing a tough test.

Expert Predictions

The experts offer diverse predictions:
Pete Prisco: “Bills win it. Pick: Bills 24, Texans 17”
Vinnie Iyer: “Pick: Bills win 23-20 but fail to cover the spread.”
Tyler Dragon from USA Today: “Pick: Bills 27, Texans 20”
Bill Bender from Sporting News: “Pick: Bills 28, Texans 17”

These predictions reflect a close game with both teams having unique strengths and weaknesses.

Conclusion

The matchup between the Buffalo Bills and Houston Texans in Week 12 promises to be an exciting contest. With key players on both sides ready for action, fans can expect a tightly contested Thursday Night Football showdown. The outcome will likely hinge on how Josh Allen performs against one of the best defenses in the league.

Follow along as the Bills aim to break their Houston jinx and solidify their position in the AFC East race, while the Texans look for a statement win at home.